Neurogenetics

Author(s)

• Geschwind, Daniel H.
• Paulson, Henry L.
• Klein, Christine

Bibliographic Information

Neurogenetics

volume editors Daniel H. Geschwind, Henry L. Paulson, and Christine Klein

（Handbook of clinical neurology, . 3rd ser. ; 147-148）

Elsevier, c2018

• pt. 1
• pt. 2

Note

Includes bibliographical references and index

Description and Table of Contents

Volume

pt. 1 ISBN 9780444632333

Description

Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist.

Table of Contents

Section I. Basic Genetic Concepts1. Clinical approach to the patient with neurogenetic disease2. Genetic and genomic testing for neurological disease in clinical practice 3. Ethical issues in neurogenetics4. Evolving views of human genetic variation and its relationship to neurologic and psychiatric disease5. Epigenetic mechanisms underlying nervous system diseases6. Pharmacogenetics7. Bioinformatics and genomic databases8. Towards precision medicine Section II. Recurring Biological Themes in Neurogenetics9. Repeat expansion diseases10. Mitochondrial diseases11. The CAG - polyglutamine repeat diseases: A clinical, molecular, genetic and pathophysiological nosology Section III. Movement Disorders12. Autosomal dominant cerebellar ataxias13. Autosomal recessive cerebellar ataxias 14. Genetics of Parkinson disease15. Essential Tremor16. Inherited dystonias: Clinical features and molecular pathways17. Huntington's Disease18. Wilson Disease and related copper disorders19. Neurodegeneration with brain iron accumulation (NBIA)20. Primary familial brain calcifications Section IV. Neurodevelopmental Disorders21. Genetics of autism spectrum disorder22. The emerging genetic landscape of cerebral palsy23. Tourette disorder and other tic disorders24. Sex chromosome aneuploidies25. Fragile X syndrome and fragile X-associated tremor ataxia syndrome

Volume

pt. 2 ISBN 9780444640765

Description

Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses.

Table of Contents

Section V. Dementias 26. The genetic landscape of Alzheimer disease 27. Frontotemporal dementia 28. The genetics of dementia with Lewy bodies 29. Prion disease Section VI. Paroxysmal Disorders 30. Genetics of epilepsy 31. Genetics of migraine 32. Periodic paralysis 33. Episodic ataxias 34. Disorders of sleep and circadian rhythms Section VII. Neuromuscular Disorders 35. Facioscapulohumeral muscular dystrophy 36. The genetics of congenital myopathies 37. Genetic basis and phenotypic features of congenital myasthenic syndromes 38. Spinal muscular atrophy 39. Emerging understanding of the genotype: Phenotype relationship in amyotrophic lateral sclerosis 40. Spinal and bulbar muscular atrophy 41. Hereditary spastic paraplegia 42. Neuropathy Section VIII. Diseases of White Matter and Demyelination 43. The spectrum of adult-onset heritable white matter disorders 44. Alexander disease 45. Neurogenetics of Pelizaeus-Merzbacher disease 46. Multiple sclerosis Section IX. Cerebrovascular Diseases 47. CADASIL Section X. Major Adult Psychiatric Disorders 48. Neuroepigenetics and addiction 49. Genetic susceptibility in obsessive-compulsive disorder Section XI. Cancer and Phakomatoses 50. Brain cancer genomics and epigenomics 51. Neurofibromatosis type 1 52. Tuberous sclerosis complex 53. Von Hippel-Lindau disease and Sturge-Weber syndrome

by "Nielsen BookData"

Details

• NCID: BB25518451
• ISBN:
  • 9780444632333
  • 9780444640765
• Country Code: ne
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Amsterdam
• Pages/Volumes: 2 v.
• Size: 27 cm
• Parent Bibliography ID:
  • BA00026041