Advances in immunology

Related Books: 15

Author(s)

Bibliographic Information

edited by W.H. Taliaferro and J.H. Humphrey

Academic Press, 1961-

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OPAC
岐阜薬科大学附属図書館

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OPAC
熊本大学附属図書館医学系分館医(2内科)

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OPAC
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OPAC
高知大学学術情報基盤図書館医学部分館

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OPAC
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OPAC
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OPAC
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OPAC
National Museum of Ethnology. Library

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OPAC
埼玉医科大学附属図書館総合医療センター

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OPAC
埼玉県立大学情報センター

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OPAC
Saitama University Library図

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OPAC
Saga University Medical Library

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OPAC
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OPAC
産業医科大学図書館図

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OPAC
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OPAC
就実大学図書館

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OPAC
昭和大学図書館

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OPAC
城西大学水田記念図書館

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OPAC
女子栄養大学図書館

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OPAC
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OPAC
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OPAC
大東文化大学 60周年記念図書館

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OPAC
千葉科学大学図書館図

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OPAC
東京科学大学大岡山図書館

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OPAC
Institute of Science Tokyo Suzukakedai Library

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OPAC
Medical Library, The University of Tokyo図書

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OPAC
Graduate School of Pharmaceutical Sciences, Pharmaceutical Sciences Library, University of Tokyo図書

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OPAC
東京農業大学生物産業学部図書館生産図

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OPAC
Tokyo University of Agriculture図

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OPAC
東京理科大学葛飾図書館葛図

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OPAC
東京理科大学野田図書館野図

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OPAC
東邦大学医学メディアセンター

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OPAC
東北医科薬科大学附属図書館

491.8/A2007492

OPAC
Tokushima University Library

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OPAC
徳島大学附属図書館蔵本分館

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OPAC
徳島文理大学図書館図

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OPAC
Tottori University Medical Library図

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OPAC
長崎県立大学シーボルト校附属図書館

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OPAC
Nagasaki University Medical library

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OPAC
長野県看護大学付属図書館図

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OPAC
Nagoya University Library医保健開架

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OPAC
新潟大学附属図書館旭町分館旭分

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OPAC
日本体育大学図書館図

v. 72491.8/A16FG471400

OPAC
日本医師会医学図書館

v. 13491.805||QW5||D79F001809

OPAC
日本大学松戸歯学部図書館

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OPAC
日本薬科大学

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OPAC
兵庫県立大学神戸情報科学学術情報館

v. 82491.8||6620005809

OPAC
Hirosaki University Medical Library

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OPAC
Hiroshima Univ. Kasumi Library

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OPAC
Hiroshima University Central Library, Interlibrary Loan国際・理工学融合

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OPAC
広島大学図書館東図書館

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OPAC
福山大学附属図書館分館

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OPAC
北海道大学医学研究科・医学部図書館研究室図書

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OPAC
北海道医療大学総合図書館

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OPAC
北海道医療大学総合図書館総図

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OPAC
防衛省防衛医科大学校図書館

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OPAC
宮崎県立看護大学附属図書館

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OPAC
Meiji University Library生

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OPAC
明治薬科大学図書館

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OPAC
安田女子大学図書館

v. 97963086

OPAC
山形大学医学部図書館

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OPAC
University of Yamanashi Library, Medical Branch図

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OPAC
横浜薬科大学図書館

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量子科学技術研究開発機構

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Note

Vol. 3-6 : edited by F. J. Dixon and F. J. Dixon

Vol. 7-36 : edited by F. J. Dixon and Henry G. Kunkel

Vol. 37-80 : edited by F. J. Dixon

Vol. 81- : edited by Frederick W. Alt

Vol. 39-48 : associate editors, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr

Vol. 49-53 : associate editors, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr, Tadamitsu Kishimoto, Fritz Melchers

Vol. 54-80 : associate editors, K. Frank Austen, Jonathan W. Uhr, Tadamitsu Kishimoto, Fritz Melchers, Frederick Alt

Vol. 81-88 : associate editors, K. Frank Austen, Tadamitsu Kishimoto, Fritz Melchers, Jonathan W. Uhr, Emil Raphael Unanue

Vol. 133- : associate editors, K. Frank Austen, Tasuku Honjo, Fritz Melchers, Hidde Ploegh, Kenneth M. Murphy

Vol. 35- : place of publication changed to Orland

Vol. 38- : place of publication changed to San Diego and Tokyo

Vol. 82- : publisher changed to Elsevier, Academic Press

Vol. 67 : cumulative subject index, volumes 37-65

Vol. 85 : cumulative subject index, volumes 66-82

Includes bibliographies and index

子書誌あり

Description and Table of Contents

Volume: v. 32 ISBN 9780120224326

Description

For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research.The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researchers and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.

Volume: v. 49 ISBN 9780120224494

Description

"Advances in Immunology" presents reviews of various topics in immunology. It not only serves to keep investigators informed, but also to unify the concepts underlying this diversified yet technically specialized subject. The volumes in this series contain reviews on different aspects of immunology, broadly defined so as to include such subjects as immunochemistry, antibody synthesis, biological actions of antibodies, immunological unresponsiveness, mechanisms in innate and acquired immunity not involving antibodies and specialized immunological techniques. The articles stress fundamental concepts, but at the same time evaluate experimental approaches. Each volume of "Advances in Immunology" contains a subject index as well as the contents of recent volumes. Each chapter includes references.

Table of Contents

The biology of bone marrow transplantation for severe combined immune deficiency, R.Parkman
adoptive T cell therapy of tumours, P.D.Greenberg
immunology and clinical importance of anti-phospholipid antibodies, H.P.McNeil et al
surface antigens of human leukocytes, V.Horejsi.

Volume: v. 50 ISBN 9780120224500

Description

Celebrating the publication of our fiftieth volume.

Table of Contents

M.D. Cooper, C.-I.H. Chen, R.P. Bucy, and C.B. Thompson, Avian T Cell Ontogeny. J.J. Cohen, Programmed Cell Death in The Immune System. T.H. Rabbitts and T. Boehm, Structural and Functional Chimerism Results from Chromosomal Translocation in Lymphoid Tumors. D.E. Mosier, Adoptive Transfer of Human Lymphoid Cells to Severely Immunodeficient Mice: Models for Normal Human Immune Function, Autoimmunity, Lymphomagenesis, and AIDS. G. Kroemer, J.L. Andreu, J.A. Gonzalo, J.C. Gutierrez-Ramos, and C. Martinez-A, Interleukin-2, Autotolerance, and Autoimmunity. A.P. Kaplan, S. Reddigari, M. Baeza, and P. Kuna, Histamine-Releasing Factors and Cytokine-Dependent Activation of Basophils and Mast Cells. C.A. Janeway, Selective Elements for the V*gb Region of the T Cell Receptor: Mis and the Bacterial Toxic Mitogens. J.S. Pober and R.S. Cotran, Immunologic Interactions of T Lymphocytes with Vascular Endothelium. Index.

Volume: v. 51 ISBN 9780120224517

Description

Table of Contents

Human Antibody Effector Function, D.R. Burton and J.M. Woof. The Development of Functionally Responsive T Cells, E.V. Rothenberg. Role of Perforin in Lymphocyte-Mediated Cytolysis, H. Yagita, M. Nakata, A. Kawasaki, Y. Shinkai, and K. Okumura. The Central Role of Follicular Dendritic Cells in Lymphoid Tissues, F. Schriever and L.M. Nadler. The Murine Autoimmune Diabetes Model: NOD and Related Strains, H. Kikutani and S. Makino. The Pathobiology of Bronchial Asthma, J.P. Arm and T.H. Lee. Chapter References. Index.

Volume: v. 52 ISBN 9780120224524

Description

Intended for researchers in immunology, cell biology, virology and medicine, this book provides information on such topics as cytokine gene regulation, and animal models for acquired immunodeficiency syndrome.

Table of Contents

Cell biology of antigen processing and presentation to MHC class 1 molecule-restricted T lymphocytes, J.W. Yewdell and J.R. Bennink
human B lymphocytes - phenotype, proliferation, and differentiation, J. Banchereau and F. Rousset
cytokine gene regulation - regulatory cis-elements and DNA binding factors involved in the interferon system, N. Tanaka and T. Taniguchi
cellular and molecular mechanisms of B lymphocyte tolerance, G.J.V. Nossal
cell surface structures on human basophils and mast cells biochemical and functional characterization, P. Valent and P. Bettelheim
animal models for acquired immunodeficiency syndrome, T.J. Kindt, et al.

Volume: v. 53 ISBN 9780120224531

Description

For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researchers and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.

Table of Contents

The Leukemia Inhibitory Factor and Its Receptor, D.P. Gearing. The Role of CD4 and CD8 in T Cell Activation and Differentiation, M.C. Miceli and J.R. Parnes. B Lymphopoiesis in the Mouse, A. Rolink and F. Melchers. Compartmentalization of the Peripheral Immune System, Immunological Memory, G. Kroemer, E. Cuende, and C. Martinez. Immunological Memory, C.R. Mackay. Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms, R.J. Ulevitch. Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus and Pemphigoid, Bullous diseases Due to Defective Epidermal Cell Adhesion, J.R. Stanley. Chapter References. Index. Contents of Recent Volumes.

Volume: v. 54 ISBN 9780120224548

Description

This volumes includes the topics of interleukin-6 biology and medicine, interleukin-9, superantigens and their potential role in human disease, interleukin-1 receptor antagonist, the mechanism and regulation of immunoglobulin isotype switching and analysis of B-cell tolerance "in vitro".

Table of Contents

S. Akira et al., Interleukin-6 Biology and Medicine. J.C. Renauld et al., Interleukin-9. B.L. Kotzin et al., Superantigens and Their Potential Role in Human Disease. W.P. Arend, Interleukin-1 Receptor Antagonist. R.L. Coffman et al., The Mechanism and Regulation of Immunoglobulin Isotype Switching. J. Lesley et al. CD44 and Its Interaction with the Extracellular Matrix. Sakaguchi et al., Immunoglobulin Receptor (IgR)-Associated Molecules. D.N. Scott, Analysis of B-Cell Tolerance in vitro. Subject Index.

Volume: v. 55 ISBN 9780120224555

Description

Approx.455 pages

Table of Contents

C-Kit Receptor Ligand. IL8 and Related Chemotactic Cytokines. TGF-B Receptors. B Cell Activation. CD5+B Cells. NK Cell Mediated Allorecognition. Imice Lacking Class I MHC Genes. Mice Lacking Class II MHC Genes. Subject Index.

Volume: v. 56 ISBN 9780120224562

Description

A Leader in Immunology

Table of Contents

T.R. Mosmann, Properties and Functions of Interleukin-10. S.M. Lewis, The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses. S.J. Anderson, S.D. Levin, and R.M. Perlmutter, Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development. K.L. Knight and M.A. Crane, Generating the Antibody Repertoire in Rabbit. A. Gaur and C.G. Fathman, Immunotherapeutic Strategies Directed at the Trimolecular Complex. F.D. Moore, Jr., Therapeutic Regulation of the Complement System in Acute Injury States. G.A. Pietersz, A. Rowland, M.J. Smyth, and I.F.C. McKenzie, Chemoimmunoconjugates for the Treatment of Cancer. R. Winchester, The Molecular Basis of Susceptibility to Rheumatoid Arthritis. P.E. Neiman, Retrovirus-Induced B Cell Neoplasia in the Bursa of Fabricus. Subject Index.

Volume: v. 57 ISBN 9780120224579

Description

A Leader in Immunology

Table of Contents

M.D. Hulett and P.M. Hogarth, Molecular Basis of Fc Receptor Function. S. Nagata, Fas and Fas Ligand: A Death Factor and Its Receptor. K. Takatsu, S. Takaki, and Y. Hitoshi, Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation. D.R. Burton and C.F. Barbas, III, Human Antibodies from Combinatorial Libraries. C. Roth, C. Rochlitz, and P. Kourilsky, Immune Response against Tumors. C.-A. Reynaud, B. Bertocci, A.Dahan, and J.-C. Weill, Formation of the Chicken B-Cell Repertoire: Ontogenesis, Regulation of Ig Gene Rearrangement and Diversification by Gene Conversion. Subject Index.

Volume: v. 58 ISBN 9780120224586

Description

This text should be a useful guide for researchers in immunology, cell and molecular biology and development biology.

Table of Contents

E.B. Kopp and S. Ghosh, NF-kB and Rel Proteins in Innate Immunity. D.T. Weaver, V(D)J Recombination and Double-Strand Break Repair. P. Kisielow and H. von Boehmer, Development and Selection of T Cells: Facts and Puzzles. G. Kroemer, The Pharmacology of T Cell Apoptosis. G.-K. Sim, Intraepithelial Lymphocytes and the Immune System. B.A. Imhof and D. Dunon, Leukocyte Migration and Adhesion. G. Dranoff and R.C. Mulligan, Gene Transfer as Cancer Therapy. Subject Index. Contents of Recent Volumes.

Volume: v. 59 ISBN 9780120224593

Description

With contributions from Steven A. Porcelli and other internationally recognized leaders in the field, this volume continues the tradition of indispensable reviews. Papers on the CD1 family, positive selection of thymocytes, and molecular and cellular aspects of XLA highlight the latest volume.

Table of Contents

S.A. Porcelli, The CD1 Family: A Third Lineage of Antigen-Presenting Molecules.P.J. Fink and M.J. Bevan, Positive Selection of Thymocytes.P. Sideras and C.I.E. Smith, Molecular and Cellular Aspects of X-Linked Agammaglobulinemia.K. Sugamura, H. Asao, M. Kondo, N. Tanaka, N. Ishii, M. Nakamura, and T. Takeshita, The Common gamma-Chain for Multiple Cytokine Receptors.C.C. Goodnow, J.G. Cyster, S.B. Hartley, S.E. Bell, M.P. Cooke, J.I. Healy, S. Akkaraju, J.C. Rathmell, S.L. Pogue, and K.P. Shokat, Self-Tolerance Checkpoints in B Lymphocyte Development.M.F. Lipscomb, D.E. Rice, C.R. Lyons, M.R. Schuyler, and D. Wilkes, The Regulation of Pulmonary Immunity.Chapter References.Subject Index.Contents of Recent Volumes.

Volume: v. 60 ISBN 9780120224609

Description

This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation.

Table of Contents

J.N. Ihle, The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling. R. Fuleihan, N. Ramesh, and R.S. Geha, X-Linked Agammaglobulinemia and Immunoglobulin Deficiency with Normal or ElevatedIgM: Immunodeficiencies of B Cell Development and Differentiation. T. Kinoshita, N. Inoue, and J. Takeda, Defective Glycosyl Phosphatidylinositol Anchor Synthesis and Paroxysmal Nocturnal Hemoglobinuria. E.H. Nardin, G.A. Oliveira, J.M. Calvo-Calle, and R.S. Nussenzweig, The Use of Multiple Antigen Peptides in the Analysis and Induction of Protective Immune Responses against Infectious Diseases. A.J. Wardlaw, R. Moqbel, and A.B. Kay, Eosinophils: Biology and Role in Disease. G. Kelsoe, In Situ Studies of the Germinal Center Reaction. H. Takayama, H. Kojima, and N. Shinohara, Cytotoxic T Lymphocytes: The Newly Identified Fas (CD95)-Mediated Killing Mechanism and a Novel Aspect of Their Biological Functions. C.R. Lyons, The Role of Nitric Oxide in Inflammation. References. Subject Index. Contents of Recent Volumes.

Volume: v. 61 ISBN 9780120224616

Description

"The series which all immunologists need."--The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching"--Journal of Immunological Methods"A provocative and scholarly review of research"--Journal of the American Medical Association"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject"--The Lancet"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."--Journal of Medical Microbiology"A very valuable serial publication...no serious student of immunology can afford to be without it."--Archives of Biochemistry and Biophysics

Table of Contents

C. van Kooten and J. Banchereau, CD40-CD40 Ligand: A Multifunctional Receptor-Ligand Pair. J. Stavnezer, Antibody Class Switching. L.M. Karnitz and R.T. Abraham, Interleukin-2 Receptor Signaling Mechanisms. M.K. Liszewski, T.C. Farries, D.M. Lublin, I.A. Rooney, and J.P. Atkinson, Control of the Complement System. K. Schwarz and C.R. Bartram, V(D)J Recombination Pathology. V. Steimle, W. Reith, and B. Mach, Major Histocompatibility Complex Class II Deficiency: A Disease of Gene Regulation. I. Aebischer and B.M. Stadler, TH1-TH2 Cells in Allergic Responses: At the Limits of a Concept. Chapter References. Subject Index. Contents of Recent Volumes.

Volume: v. 62 ISBN 9780120224623

Description

The Leader in Immunology Reviews

Table of Contents

F. Matsuda and T. Honjo, Organization of the Human Immunoglobulin Heavy-Chain Locus.J. Chen, Analysis of Gene Function in Lymphocytes by RAG-2-Deficient Blastocyst Complementation.A. Billiau, Interferon-gamma: Biology and Role in Pathogenesis.K.S. Hathcock and R.J. Hodes, Role of the CD28-B7 Costimulatory Pathways in T Cell-Dependent B Cell Responses.W.L. Smith and D.L. DeWitt, Prostaglandin Endoperoxide H Synthases-1 and -2.R.A. Hendersonand O.J. Finn, Human Tumor Antigens Are Ready to Fly.N.W. Lukacs and P.A. Ward, Inflammatory Mediators, Cytokines, and Adhesion Molecules in Pulmonary Inflammation and Injury.Chapter References.Subject Index.Contents of Recent Volumes.

Volume: v. 63 ISBN 9780120224630

Description

Praise for the Series: "The series which all immunologists need." --The Pharmaceutical Journal "Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science "Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Table of Contents

H. Karasuyama, A. Rolink, and F. Melchers, Surrogate Light Chain in B Cell Development. L. Clark, T.M. Foy, and R.J. Noelle, CD40 and Its Ligand. D.E. Mosier, Human Immunodeficiency Virus Infection of Human Cells Transplanted to Severe Combined Immunodeficient Mice. C. Martinez-A., A. Rebollo, and J. Gomez, Lessons from Immunologicale Biochemical, and Molecular Pathways of the Activation Mediated by IL-2 and IL-4. D. Opstelten, B Lymphocyte Development and Transcription Regulation in Vivo. R. Fernandez-Botran, P.M. Chilton, and Y. Ma, Soluble Cytokine Receptors: Their Roles in Immunoregulatione Disease and Therapy. L.B. Ivashkiv, Cytokine Expression and Cell Activation in Inflammatory Arthritis. R. Kooijman, E.L. Hooghe-Peters, and R. Hooghe, Prolactine Growth Hormonee and Insulin-like Growth Factor-I in the Immune System. Chapter References. Subject Index.

Volume: v. 64 ISBN 9780120224647

Description

This volume in the "Advances in Immunology" series presents recent findings related to the roles of proteasomes in the MHC class I-restricted antigen processing pathway and discusses recent observations and insights on V(D)J recombination. It also examines the structure, function and mechanisms of regulation of mammalian Ets transcription factors and the processes of b2m assembly and peptide loading and the involving molecules. Current concepts and enigmas of lymphocyte homing as well as a description of plasmacytomagenesis in mice and insights into the cellular and molecular biology of human plasma cell dyscrasias are included. In addition, the work provides a summary of the rationale for anti TNFa antibody therapy and its clinical effects.

Table of Contents

K. Tanaka, Proteasomes and Antigen Processing. M. Gellert, Recent Advances in Understanding V(D)J. A.G. Bassuk and J.M. Leiden, The Role of Ets Transcription Factors in the Development and Function of Mammalian Immune System. T.H. Hansen and D.R. Lee, Mechanism of Class I Assembly with (2m and Loading with Peptide. M. Salmi and S. Jalkanen, How Do Lymphocytes Know Where to Go: Current Concepts and Enigmas of Lymphocyte Homing. N. Nishimoto, S. Suematsu, and T. Kishimoto, Plasma Cell Dyscraisas. M. Feldman, M.J. Elliott, J.N. Woody, and R.N. Maini, Anti TNF( Therapy of Rheumatoid Arthritis. Chapter References. Subject Index.

Volume: v. 65 ISBN 9780120224654

Description

Ig A DeficiencyThe Role of Cellular Immunity in Protection against HIV InfectionMouse Mammary Tumour Virus: Immunological Interplays between Virus and HostThe Transporter Associated with Antigen ProcessingNF-kB in cytokine gene expressionNF-kB as a target for immunosuppressive and anti-inflammatory molecules

Table of Contents

S. Akira and T. Kishimoto, NF-IL6 and NF-k B in Cytokine Gene Regulation. T. Elliott, The Transporter Associated with Antigen Processing (TAP). P. Baiuerle and A.V.R. Baichwal, NF-k B as Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules. S. Luther and H. Acha-Orbea, Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host. P.D. Burrows and M.D. Cooper, Ig A Deficiency. S. Rowland-Jones, R. Tan, and A. McMichael, The Role of Cellular Immunity in Protection against HIV Infection. G. Kraal and R.E. Mebius, High Endothelial Venules Lymphocyte Traffic Control and Controlled Traffic. Chapter References. Subject Index.

Volume: v. 66 ISBN 9780120224661

Description

This volume centres on advances in immunology. Topics covered include: the role of cytokines in sepsis; CD8+ cells in HIV pathogenesis; and the role of CD45 in signal transduction.

Table of Contents

L.B. Justement, The Role of CD45 in Signal Transduction. J. Hammer, T. Sturniolo, and F. Sinigaglia, HLA Class II Peptide Binding Specificity and Autoimmunity. C.E. Hack, L.A. Aarden, and L.G. Thijis, The Roleof Cytokines in Sepsis. C.N. Metz and R. Bucala, The Role of MIF in the Regulation of the Immune Response. A.P. Kaplan, K. Joseph, Y. Shibayama, S. Reddigari, B. Ghebrehiwet, and M. Silverberg, The Intrinsic Coagulation-Kinin Forming Cascade:Assembly in Plasma and Cell Surfaces in Inflammation. O.O. Yang and B.D. Walker, CD8+ Cells in HIV Pathogenesis: Cytolytic and Non-Cytolytic Inhibition of Viral Replication.

Volume: v. 67 ISBN 9780120224678

Description

This volume comprises the cumulative subject index for volumes 37 to 65 of the "Advances in Immunology" series.

Table of Contents

Cumulative Subject Index, Volumes 37-65.

Volume: v. 68 ISBN 9780120224685

Description

This work on recent advances in immunology covers topics which include: mRNAs relevant to T-cell function, the pharmacology of T-cell apoptosis, prenylation of ras GTpase superfamily proteins and their function in immunobiology, and immunological treatment of autoimmune diseases.

Table of Contents

J.S. Malter, mRNAs Relevant to T-Cell Function. G. Kroemer and J.M. Penninger, The Pharmacology of T-Cell Apoptosis. R.B. Lobell, Prenylation of Ras GTPase Superfamily Proteins and Their Function in Immunobiology. F. Momburg and G.J. Hammerling, Generation and TAP-mediated Transport of Peptides for MHC Class I Molecules. T. Brocker and K. Karjalainen, Adoptive Tumor Immunity Mediated by Lymphocytes Bearing Modified Antigen Specific Receptors. A.J. McNight and S. Gordon, Membrane Molecules as Differentiation Antigens of Murine Macrophages. G.T. Nepom, MHC-Directed Susceptibility to Rheumatoid Arthritis. J.R. Kalden, F.C. Breedveld, H. Burkhardt, and G.R. Burmester, Immunological Treatment of Autoimmune Diseases. Subject Index.

Volume: v. 69 ISBN 9780120224692

Description

This work on recent advances in immunology covers topics which include: molecular and cellular events in early thymocyte development; regulation of ig light chain isotype expression; and the role of immuno-receptor tyrosine-based activation motif (ITAM) in signal transuction.

Table of Contents

H.-R. Rodewald, Molecular and Cellular Events in Early Thymocyte Development. F. Alt and J.R. Gorman, Regulation of Ig Light Chain Isotype Expression. N. Isakov, The Role of Immunoreceptor Tyrosine-based Activation Motif (ITAM) in Signal Transduction from Antigen and Fc Receptors. G.J. Arlaud, Y. Xu, J.E. Volanakis, V. Rossi, N.M. Thielens, and S.V.L. Narayana, The Atypical Serine Proteases of the Complement System. R. Tripathi, N. Mathieu, I. Leduc, W.M. Hempel, and P. Ferrier, Accessibility Control of V(D)J Recombination: Lessons from Gene Targeting. J.S. Bromberg, L. Qin, and L.A. DeBruyne, Interactions Between the Immune System and Gene Therapy Vectors: Bidirectional Regulation of Response and Expression. D. Penn and W. Potts, MHC Genes Influence Individual Odors and Mating Preferences. A. Chess, Olfactory Receptor Gene Regulation. Subject Index.

Volume: v. 70 ISBN 9780120224708

Description

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

D.M. Willerford and B.H. Nelson, The Biology of the Interlukin-2 Receptor. G. Trinchieri, Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity. C.B. Thompson, A.J. Minn, R.E. Swain, and A. Ma, Recent Progress on the Regulation of Apoptosis by Bcl-2 Family Members. H. Okamura, H. Tsutsui, S. Kashiwamura, T. Yoshimoto, and K. Nakanishi, Interleukin-18 (IL-18): A Novel Cytokine that Augments Both Innate and Acquired Immunity. A. Oxenius, R.M. Zinkernagel, and H. Hengartner, CD4 + T Cell Induction and Effector Functions: A Comparison of Immunity Against Soluble Antigens and Viral Infections. P.J. Peters and V.W. Hsu, Current Views in Intracellular Transport: Insights from Studies in Immunology. J.J. Marchalonis, S.F. Schulter, R.M. Bernstein, S. Shen, and A.B. Edmundson, Phylogenetic Emergence and Molecular Evolution of the Immunoglobulin Family. D. Kandiah, A. Sali, Y. Sheng, E.J. Victoria, D.M. Marquis, and S.M. Coutts, Current Insights Into the 'Antiphospholipid' Syndrome: Clinical, Immunological and Molecular Aspects. Subject Index.

Volume: v. 71 ISBN 9780120224715

Description

Table of Contents

D.M. Willerford and B.H. Nelson, The Biology of the Interleukin-2 Receptor. G. Trinchieri, Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity. C.B. Thompson, A.J. Minn, R.E. Swain, and A. Ma, Recent Progress on the Regulation of Apoptosis by Bcl-2 Family Members. H. Okamura, H. Tsutsui, S.-I. Kashiwamura, T. Yoshimoto, and K. Nakanishi, Interleukin-18 (IL-18): A Novel Cytokine that Augments Both Innate and Acquired Immunity. A. Oxenius, R.M. Zinkernagel, and H. Hengartner, CD4 + T Cell Induction and Effector Functions: A Comparison of Immunity Against Soluble Antigens and Viral Infections. P.J. Peters and V.W. Hsu, Current Views in Intracellular Transport: Insights From Studies in Immunology. J.J. Marchalonis, S.F. Schulter, R.M. Bernstein, S. Shen, and A.B. Edmundson, Phylogenetic Emergence and Molecular Evolution of the Immunogolbulin Family. D. Kandiah, A. Sali, Y. Sheng, E.J. Victoria, D.M. Marquis, and S.M. Coutts, Current Insights Into the 'Antiphospholipid' Syndrome: Clinical, Immunological, and Molecular Aspects. Subject Index.

Volume: v. 72 ISBN 9780120224722

Description

Table of Contents

Amon Altman and Marcel Derkert, The Functions of Small GTPases in Signaling by Immune Recognition and Other Leukocyte Receptors. Bernard Malissen, Laurence Ardouin, Shih-Yao Lin, Anne Gillet, and Marie Malissen, Function of the CD3 Subunits of the Pre-TCR and TCR Complexes During T-Cell Development. Jeffery V. Ravetch and Silvia Bolland, Inhibitory Pathways Triggered by ITIM-Containing Receptors. Yang Xu, ATM in Lymphoid Development and Tumorigenesis. Alexander McPherson, Lisa A. Harris, and Steven B. Larson, Comparison of Intact Antibody Structures and the Implications for Effector Function. Eugene C. Butcher, Marna Williams, Kenneth Youngman, Lusijah Rott, and Michael Briskin, Lymphocyte Trafficking and Regional Immunity. Jaques Banchereau, Diana Bell, and James W. Young, Dendrite Cells. Yoji Shimizu, David M. Rose, and Mark H. Ginsberg, Integrins in the Immune System.

Volume: v. 73 ISBN 9780120224739

Description

Table of Contents

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo:Implications for Generating CD*+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines, J.W. Yewdell, C.C. Norbury and J.R. Bennink. Signal Transduction Pathways That Regulate the Fate of B Lymphocytes, A. Craxton, K. Otipoby, A. Jiang and E.A. Clark. Oral Tolerance: Mechanisms and Therapeutic Applications, A. Faria and H.L. Weiner. Caspases and Cytokines: Roles in Inflammation and Autoimmunity, J.C. Reed. T Cell Dynamics in HIV-1 Infection, D.R. Clark, R.J. DeBoer, K.C. Wolthers and F. Miedema. Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger, H. Wagner. Neutrophil-Derived Proteins: Selling Cytokines by the Pound, M.A. Cassatella. Murine Models of Thymic Lymphomas: Premalignant Scenarios Amendable to Prophylactic Therapy, E. Yefenof. Index. Contents of Recent Volumes.

Volume: v. 74 ISBN 9780120224746

Description

Table of Contents

K. Ishizaka, Y. Ishii, T. Nakano, and K. Sugie, Biochemical Basis of Antigen-Specific Suppressor T Cells Factors. M. Carroll, The Role of Complement in B Cell Activation and Tolerance. D. Nemazee, Receptor Editing in B Cells. M. Baggiolini, B. Moser, and P. Loetscher, Chemokines and Their Receptors in Lymphocyte Traffic and HIV Infection. S. Ferrone, F.M. Marincola, E. Jaffee, D.J. Hicklin, Escape of Human Solid Tumors from T Cell Recognition: Molecular Mechanisms and Functional Significance. W. Solbach and Y. Laskay, The Host Response to Leishmania Infection.

Volume: v. 75 ISBN 9780120224753

Description

Volume: v. 76 ISBN 9780120224760

Description

Table of Contents

The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction. Raft Membrane Domains and Immunoreceptor Functions. Human Basophils: Mediator release and cytokin production. Btk and BLNK in B cell development. Diversity and Regulatory Functions of Mammalian Secretory Phospholipase A2s. Mouse Models of Allergic Airway Disease. Selected Comparison of Immune and Nervous System Development.

Volume: v. 77 ISBN 9780120224777

Description

Table of Contents

Contributors. The Actin Cytoskeleton, Membrane Lipid Microdomains, and T Cell signal Transduction, S.C.P. Morley and B.E. Bierer. Raft Membrane Domains and Immunoreceptor Functions, T. Harder. Human Basophils: Mediator Release and Cytokine Production, J.T. Schroeder, D.W. MacGlashan, Jr., and L.M. Lichtenstein. Btk and BLNK in B Cell Development, S. Tsukada, Y. Baba, and D. Watanabe. Diversity and Regulatory Functions of Mammalian Secretory Phospholipase A,sub>2S, M. Murakami and I. Kudo. The Antiviral Activity of Antibodies in Vitro and in Vivo, P.W.H.I. Parren and D.R. Burton. Mouse Models of Allergic Airway Disease, C.M. Lloyd, J.-A. Gonzalo, A.J. Coyle, and J.-C. Gutierrez-Ramos. Selected Comparison of Immune and Nervous System Development, J. Chun. Index. Contents of Recent Volumes.

Volume: v. 78 ISBN 9780120224784

Description

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.

Table of Contents

Toll-like Receptors and Innate Immunity Chemokines in Immunity Attractions and Migrations of Lymphoid Cells in the Organization of Humoral Immune Responses Factors and Forces Controlling V(D)J Recombination T Cell Effector Subsets: Extending the Th1/Th2 Paradigm MHC-Restricted T Cell Responses against Posttranslationally Modified Peptide Antigens Gastrointestinal Eosinophils in Health and Disease Index Contents of Recent Volumes

Volume: v. 79 ISBN 9780120224791

Description

Volume: v. 80 ISBN 9780120224807

Description

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Volume: v. 81 ISBN 9780120224814

Description

Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries.

Table of Contents

Preface Frederick W. Alt Regulation of the immune response by the 'interaction of chemokines and proteases Molecular mechanisms of host-pathogen interaction: Entry and survival of mycobacteria in macrophages B Lymphoid Neoplasms of Mice: Charac'teristics of Naturally Occurring and Engineered Diseases and Relationships to Human disorders Prions and the immune system: a journey through gut spleen, and nerves Roles of the Semaphorin Family in immune regulation HLA-G molecules: from maternal-fetal tolerance to tissue acceptance The Zebrafish as a model organism to study development of the immune system Control of autoimmunity by naturally arising regulatory CD4+ T cells

Volume: v. 82 ISBN 9780120224821

Description

Table of Contents

Transcriptional regulation in neutrophils: Teaching old cells new tricks Tumor vaccines Immunotherapy of allergic disease Interactions of immunoglobulins outside the antigen-combining site The role of antibodies in mouse models of rheumatoid arthirits, and relevance to human disease MUC1 Immunobiology: from discovery to clinical applications Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (Hyper-IgM syndromes) The Biologic Role of C1 Inhibitor in Regulation of Vascular Permeability and Modulation of Inflammation

Volume: v. 84 ISBN 9780120224845

Description

Table of Contents

Interactions between NK Cells and B Lymphocytes Multitasking of helix-loop-helix proteins in lymphopoiesis Customized antigens for desensitizing allergic patients The immune response atainst dying tumor cells HMGB1 in the Immunology of Sepsis (not Spetic Shock) and Arthritis Selection of the T cell repertoire: Receptor-controlled checkpoints in T cell development The pathogenesis of Diabetes in the NOD Mouse

Volume: v. 85 ISBN 9780120224852

Description

Table of Contents

Contents of Volumes 66-82Cumulative Subject Indexes for 66-82Contributors to Volumes 66-82

Volume: v. 86 ISBN 9780120224869

Description

"Advances in Immunology", a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. The articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. It is now available online! It is a highly respected review series with an impact factor in 2003 of 7.424 and ranked number 8/114. The new editor is Frederick Alt.

Table of Contents

Adenosine Deaminase Deficiency: Metabolic Basis of Immune Deficiency and Pulmonary Inflammation Mechanism and Control of V(D)J Recombination Versus Class Switch Recombination: Similarities and Differences Isoforms of Terminal deoxynucleotidyl transferase: Developmental aspects and function Innate Autoimmunity Formation of Bradykinin: A Major Contributor to the Innate Inflammatory Response IL-2, IL-15 and Their Roles in Human Natural Killer Cells Regulation of Antigen Presentation and Cross-presentation in the Dendritic Cell Network: Facts, Hypothesis, and Immunological Implications

Volume: v. 87 ISBN 9780120224876

Description

Advances in Immunology, a long established and highly respected series, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

New Systems of Variablity and DiversityArtemisMismatch Repair Proteins and Switch Sequences in Class Switch RecombinationMolecular characterization and classificationThe integration of conventional and unconventional T cell responsesThe LAT adaptor in T cell development

Volume: v. 88 ISBN 9780120224883

Description

Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

CD22: A Multi-Functional Receptor that RegulatesB Lymphocyte Survival and Signal TransductionTetramer analysis of human autoreactive CD4 positive T cellsRegulation of Phospholipase C-fx2 networks in B lymphocytesRole of Human Mast Cells and Basophils in Bronchial AsthmaA novel recognition system for MHC class I molecules constituted by PIRDendric Cell BiologyThe Murine Diabetogenic Class II Histocompatibility Molecule I-Ag7: Structural and Functional Properties and Specificity of Peptide Selection RNAi and RNA-based regulartionof immune system function

Volume: v. 89 ISBN 9780120224906

Description

Table of Contents

Post-transcriptional Mechanisms Regulating the Inflammatory ResponseNegative signaling in Fc Receptor complexesThe Surprising Diversity of Lipid Antigens for CD1-restricted T cells Lysophospholipids as Mediators of ImmunitySystemic MastocytosisRegulation of Fibrosis by the Immune SystemImmunity and acquired alterations in cognition and emotion: Lessons from SLEImmunodeficiencies with autoimmune consequences

Volume: v. 91 ISBN 9780120224913

Description

Table of Contents

A Reappraisal of Humoral Immunity Based on Mechanisms of Antibody-Mediated Protection Against Intracellular PathogensAccessibility Control of V(D)J Recombination Targeting Integrin Structure and Function in DiseaseEndogenous TLR-ligands and AutoimmunityGenetic Analysis of Innate ImmunityTIM family of genes in Immunity and ToleranceInhibition of Inflammatory Responses by Leukocyte Ig-like Receptors

Volume: v. 92 ISBN 9780123736369

Description

Table of Contents

Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease Avian Models with Spontaneous Autoimmune Diseases Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation The Human T Cell Response to Melanoma Antigens Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions Index Contents of Recent Volumes

Volume: v. 93 ISBN 9780123737076

Description

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Volume: v. 95 ISBN 9780123737083

Description

Table of Contents

Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development Tolerance and Autoimmunity: Lessons at the bed-side of Primary Immunodeficiencies B cell self-tolerance in humans Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies Osteoimmunology: a view from the bone Mast Cell Proteases

Volume: v. 96 ISBN 9780123737090

Description

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Volume: v. 97 ISBN 9780123743244

Description

Table of Contents

T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes Subject Index Contents of Recent volumes

Volume: v. 99 ISBN 9780123743251

Description

Table of Contents

1. Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus Thomas Perlot and Frederick W. Alt 2. DNA-PK: The means to justify the ends? Katheryn Meek, Van Dang, and Susan P. Lees-Miller 3. Thymocyte selection including the new proteosome system Yousuke Takahama 4. Myocarditis Noel R. Rose 5. IL-17 Casey Weaver 6. TSLP and determinants of a Th2 host response Yong-Jun Liu

Volume: v. 98 ISBN 9780123743312

Description

Table of Contents

1. Immune regulation by B cells and antibodies: a view towards the clinic Kai Hoehlig, Vasiliki Lampropoulou, Toralf Roch, Patricia Neves, Elisabeth Calderon-Gomez, Stephen M. Anderton, Ulrich Steinhoff, Simon Fillatreau 2. Cumulative Environmental Changes, Antigen Exposure, and the Increase of Allergy Tse Wen Chang and Ariel Y. Pan 3. FceR1 signalling *tentative title* J. Rivera 4. TCR triggering mechanism *tentative title* Kai W. Wucherpfennig 5. IL-17 *tentative title* Casey Weaver

Volume: v. 101 ISBN 9780123747938

Description

Table of Contents

1. TSLP in Epithelial cell and Dendritic Cell Cross Talk Yong-Jun Liu 2. Natural Killer Cell Tolerance: Licensing and Other Mechanisms A. Helena Jonsson and Wayne M. Yokoyama 3. Biology of the Eosinophil Carine Blanchard and Marc E. Rothenberg 4. Basophils: Beyond Effector Cells of Allergic Inflammation John T. Schroeder 5. AID DNA targets Ali A. Zarrin, Jason Hackney, Kate Senger, Christopher Garris, Yonglian Sun, Maria N. Lorenzo, and Shahram Misaghi

Volume: v. 102 ISBN 9780123748010

Description

Volume: v. 103 ISBN 9780123748324

Description

Table of Contents

DNA double strand break responses to breaks during V(D)J recombination Barry Sleckman Regulation of T cell responsiveness and anergy by reversible palmitoylation Amnon Altman Polysaccharide antigens
immune responses to commensals Dennis Kasper Chromosomal Architecture and Positioning and Control of V(D)J recombination Jane Skok

Volume: v. 104 ISBN 9780123750310

Description

Table of Contents

Table of Contents 1. Polysaccharide antigens
immune responses to commensals Dennis Kasper 2. Crosstalk between NK and Dendritic Cells Harvey Cantor 3. Regulation of T cell responsiveness and anergy by reversible palmitoylation Amnon Altman 4. The Amplification Loop of the Complement Pathway Sir Peter Lachmann

Volume: v. 108 ISBN 9780123809957

Description

Volume: v. 105 ISBN 9780123813022

Description

Table of Contents

Learning from leprosy: insight into the human innate immune response Dennis Montoya and Robert L. Modlin 2. The immunological functions of saposins Alexandre Darmoise, Patrick Maschmeyer and Florian Winau OX40-OX40 ligand interaction in T cell-mediated immunity and immunopathology Naoto Ishii, Takeshi Takahashi, Pejman Soroosh, and Kazuo Sugamura 4.The family of IL-10-secreting CD4+ T cells Keishi Fujio, Tomohisa Okamura, and Kazuhiko Yamamoto 5.Artificial engineering of secondary lymphoid organs Jonathan K.H. Tan and Takeshi Watanabe 6. Aid And Somatic Hypermutation Robert W. Maul and Patricia J. Gearhart 7. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis Katia Basso and Riccardo Dalla-Favera

Volume: v. 106 ISBN 9780123813046

Description

Volume: v. 111 ISBN 9780123859914

Description

Table of Contents

Contributors Early Steps of Follicular Lymphoma Pathogenesis 1. Follicular Lymphoma 2. The Classical Model of Follicular Lymphomagenesis 3. Circulating and Resident t(14
18) Cells Detected in Healthy Individuals are not Naive B-Cells 4. The "Allelic Paradox": A Particular Immuno/Genophenotype of t(14
18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood 5. A Fraction of t(14
18) Cells in Healthy Carriers are Developmentally "Blocked" Follicular Lymphoma-Like Cells (FLLC) 6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor 7. Trafficking, Early Dissemination, and Progression 8. A Protracted Model of Multi-Hit FL Genesis 9. Perspectives Acknowledgments "A Rose is a Rose is a Rose," but CVID is Not CVID 1. Introduction 2. Definition and Diagnostic Criteria 3. Epidemiology 4. Pathophysiology/Immunopathology 5. Etiology/Genetics 6. CVID Classification Schemes 7. Clinical Presentation and Complications 8. Management 9. Prognosis and Survival 10. Summary Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development Abbreviations 1. Introduction: Cancer as a Genetic Disease 2. Nucleotide-Editing Enzymes as Inducers of Mutations 3. Physiologic Roles of AID in Antibody Production 4. Regulation of AID Expression in B Cells 5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis 6. Roles of AID in Inflammation-Associated Human Carcinogenesis 7. Role of AID in the Development of Hematopoietic Malignancy 8. Conclusion Acknowledgments Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods 1. Introduction 2. Structure and Function of Antibodies 3. Ig-Heavy Chain in Tetrapods 4. Ig-Light Chains in Tetrapods 5. Evolution of Immunoglobulin J-Chain 6. Noncanonical Antibodies in Camelids 7. Concordance and Divergence of the Generation of Antibody Diversity 8. Concluding Remarks Acknowledgments Pax5 1. Pax5 and B Cell Commitment 2. Pax5 and the Control of Igh Rearrangements 3. Pax5 and Late B Cell Development 4. Role of Pax5 in B Cell Malignancies 5. Perspective Acknowledgments

Volume: v. 110 ISBN 9780123876638

Description

Table of Contents

Modeling a Complex Disease: Multiple Sclerosis Florian C. Kurschus, Simone Woertge and Ari Waisman The IgH Locus 3' Regulatory Region: Pulling the Strings from Behind Eric Pinaud, Marie Marquet, Remi Fiancette, Sophie Peron, Christelle Vincent-Fabert, Yves Denizot and Michel Cogne Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice Ichiro Taniuchi and Wilfried Ellmeier Autoinflammation by Endogenous DNA Shigekazu Nagata and Kohki Kawane AID targeting in Antibody Diversity Rushad Pavri and Michel C. Nussenzweig

Volume: v. 109 ISBN 9780123876645

Description

Table of Contents

Dynamic Palmitoylation and the Role of DHHC Proteins in T Cell Activation and Anergy Natural Killer Cell Development and Function The Control of Adaptive Immune Responses by the Innate Immune System The Evolution of Adaptive Immunity in Vertebrates T Helper Cell Differentiation

Volume: v. 115 ISBN 9780123942999

Description

Table of Contents

The Immunobiology of IL-27Aisling O'Hara Hall, Jonathan S. Silver, and Christopher A. Hunter Autoimmune Arthritis: The Interface between the Immune System and JointsNoriko Komatsu and Hiroshi Takayanagi Immunological Tolerance during Fetal Development: From Mouse to ManJeff E. Mold and Joseph M. McCune Mapping Lupus Susceptibility Genes in the NZM2410 Mouse ModelLaurence Morel Functional Heterogeneity in the Basophil Cell LineageMark C. Siracusa, Elia D. Tait Wojno & David Artis An Emerging Role of RNA-Binding Proteins as Multifunctional Regulators of Lymphocyte Development and FunctionMartin Turner and Daniel Hodson Active and Passive Anti-cytokine Immune Therapies Current Status and DevelopmentHelene Le Buanec, Armand Bensussan, Martine Bagot, Robert C. Gallo, Daniel Zagury

Volume: v. 116 ISBN 9780123943002

Description

Table of Contents

Classical and Alternative End Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks Cristian Boboila, Frederick W. Alt and Bjoern Schwer The Leukotrienes Immune Modulating Lipid Mediators of Disease Antonio Di Gennaro and Jesper Z. Haeggstroem Gut Microbiota Drives Metabolic Diseases in Immunologically Altered Mice Benoit Chassaing, Jesse D Aitken, Andrew T Gewirtz and Matam Vijay-Kumar What is Unique about the IgE Response? Huizhong Xiong, Maria A. Curotto de Lafaille and Juan J. Lafaille Prostanoids as Regulators of Innate and Adaptive Immunity Takako Hirata and Shuh Narumiya Lymphocyte Developmental: Integration of DNA Damage Response Signaling Jeffrey J. Bednarski and Barry P. Sleckman

Volume: v. 119 ISBN 9780124077072

Description

Table of Contents

The Interdisciplinary Science of T-Cell Recognition Johannes B. Huppa and Mark M. Davis Residual Immune Dysregulation Syndrome in Treated HIV Infection Michael M. Lederman, Nicholas T. Funderburg, Rafick P. Sekaly, Nichole R. Klatt and Peter W. Hunt Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells Adrian Liston and Ciriaco A. Piccirillo Logic of the Inflammation-Associated Transcriptional Response Alexander Tarakhovsky Structural Basis of Signal Transduction in the TNF Receptor Superfamily Jixi Li, Qian Yin and Hao Wu

Volume: v. 118 ISBN 9780124077089

Description

Table of Contents

Negative regulation of autoreactive peripheral B cells Betty Diamond Epigenetic regulation of cytokine gene expression Anne Goldfeld and Laurens Kruidenier Rheumatoid Arthritis and roles of Citrulilinated auto-proteins Lars Klareskog

Volume: v. 117 ISBN 9780124105249

Description

Table of Contents

Mechanisms of Epigenetic Regulation of Leukemia Onset and Progression Panagiotis Ntziachristos, Jasper Mullenders, Thomas Trimarchi, and Iannis Aifantis Translocations in Normal B Cells and Cancers: Insights from New Technical Approaches Roberto Chiarle The Intestinal Microbiota in Chronic Liver Disease Jorge Henao-Mejia, Eran Elinav, Christoph A. Thaiss, and Richard A. Flavell Intracellular Pathogen Detection by RIG-I-like Receptors Evelyn Dixit and Jonathan C. Kagan

Volume: v. 121 ISBN 9780128001004

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Table of Contents

Multifarious Determinants of Cytokine Receptor Signaling Specificity Ignacio Moraga, Jamie Spangler, Juan Mendoza and K. Christopher Garcia Pathogenic Mechanisms of Bradykinin Mediated Diseases: Dysregulation of an Innate Inflammatory Pathway Allen P. Kaplan and Kusumam Joseph The Role of Short-Chain Fatty Acids in Health and Disease Jian Tan, Craig McKenzie, Maria Potamitis, Alison N. Thorburn, Charles R. Mackay and Laurence Macia Combined Immunodeficiencies with Non-Functional T Lymphocytes Luigi D. Notarangelo The CD200-CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host-Pathogen Interactions Christine A. Vaine and Roy J. Soberman Immunopathogenesis of Neuromyelitis Optica Michael Levy, Benjamine Arellano, Brigitte Wildemann, Sven Jarius, Saranya Sasidharan, Martin Weber and Olaf Stuve

Volume: v. 124 ISBN 9780128001479

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Table of Contents

Group 2 Innate Lymphoid Cells in the Lung Li Yin Drake and Hirohito Kita The Ubiquitin System in Immune Regulation Yoon Park, Hyung-seung Jin, Daisuke Aki, Jeeho Lee and Yun-Cai Liu How Immunoglobulin G Antibodies Kill Target Cells: Revisiting an Old Paradigm Markus Biburger, Anja Lux and Falk Nimmerjahn A Transendocytosis Perspective on the CD28/CTLA-4 Pathway Blagoje Soskic, Omar S. Qureshi, Tiezheng Hou and David M. Sansom How to Trigger a Killer - Modulation of Natural Killer Cell Reactivity on Many Levels Carsten Watzl Roles for Helper T Cell Lineage-Specifying Transcription Factors in Cellular Specialization Amy S. Weinmann MHC Class I Recognition by Monocyte/Macrophage-Specific Receptors Ryotaro Yoshida Regulation of Regulatory T Cells: Epigenetics and Plasticity Masahiro Okada, Sana Hibino, Kazue Someya and Akihiko Yoshmura

Volume: v. 122 ISBN 9780128002674

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Table of Contents

Regulation of Immunoglobulin Class Switch Recombination: Choreography of Non-Coding Transcription, Targeted DNA Deamination and Long-Range DNA RepairAllysia Matthews, Simin Zheng, Lauren DiMenna and Jayanta Chaudhuri Two Forms of Adaptive Immunity in Vertebrates: Similarities and DifferencesMasanori Kasahara and Yoichi Sutoh Recognition of Tumors by the Innate Immune System and Natural Killer CellsAssaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin and David H. Raulet Signaling Circuits in Early B Cell Development Michael Reth and Peter Nielsen Interleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and HumansDror S. Shouval, Jodie Ouahed, Amlan Biswas, Jeremy A. Goettel, Bruce Horwitz, Alexio M. Muise and Scott B. Snapper Development of Mast Cells and Importance of their Tryptase and Chymase Serine Proteases in Inflammation and Wound HealingJeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis and Richard L. Stevens Why does Somatic Hypermutation by AID Require Transcription of its Target Genes?Ursula Storb

Volume: v. 125 ISBN 9780128022436

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Table of Contents

1. Regulation of CD4 and CD8 Co-receptor Expression and CD4 Versus CD8 Lineage Decisions Takeshi Egawa 2. Mast Cells' Integrated Actions with Eosinophils and Fibroblasts in Allergic Inflammation: Implications for Therapy Nadine Landolina, Roopesh Singh Gangwar and Francesca Levi-Schaffer 3. Positive-selection-Inducing Self-peptides Displayed by Cortical Thymic Epithelial Cells Kensuke Takada and Yousuke Takahama 4. Group 2 Innate Lymphoid Cells in the Regulation of Immune Responses Ben Roediger and Wolfgang Weninger 5. Microbes and B Cell Development Duane R. Wesemann

Volume: v. 126 ISBN 9780128022443

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Table of Contents

1. NOD.H-2h4 Mice: An Important and Underutilized Animal Model of Autoimmune Thyroiditis and Sjogren's Syndrome Helen Braley-Mullen and Shiguang Yu 2. Approaches for Analyzing the Roles of Mast Cells and their Proteases in vivo Stephen J. Galli, Mindy Tsai, Thomas Marichal, Elena Chugunova, Laurent Reber and Gunnar Pejler 3. Epithelial Cell Contributions to Intestinal Immunity Lora V. Hooper 4. Innate Memory T Cells Stephen C. Jameson, You Jeong Lee and Kristin A. Hogquist

Volume: v. 127 ISBN 9780128022450

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Table of Contents

Cross-Presentation in Mouse and Human Dendritic CellsElodie Segura and Sebastian Amigorena HLA-G: An Immune Checkpoint MoleculeEdgardo D. Carosella, Nathalie Rouas-Freiss, Diana Tronik-Le Roux, Philippe Moreau and Joel LeMaout Activation and Function of iNKT and MAIT CellsShilpi Chandra and Mitchell Kronenberg IgE and Mast Cells: the Endogenous AdjuvantHans C. Oettgen and Oliver T. Burton RNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeEvangelos Pefanis and Uttiya Basu

Volume: v. 132 ISBN 9780128047972

Description

Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews on immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Table of Contents

1. Context- and Tissue-Specific Regulation of Immunity and Tolerance by Regulatory T Cells A. Ulges, E. Schmitt, C. Becker and T. Bopp 2. Endogenous Retroelements and the Host Innate Immune Sensors X. Mu, S. Ahmad and S. Hur 3. B-Lymphopoiesis in Fetal Liver, Gudied by Chemokines K. Kajikhina, M. Tsuneto and F. Melchers 4. The Role of the Secreted Phospholipase A2 Gene Family in Immunology M. Murakami, K. Yamamoto, Y. Miki, R. Murase, H. Sato and Y. Taketomi 5. Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses J. R. Teijaro

Volume: v. 131 ISBN 9780128047989

Description

Table of Contents

1. Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis Nikolina Papac Milicevic, Clara Jana-Lui Busch and Christoph J. Binder 2. Factors That Regulate the Generation of Antibody-Secreting Plasma Cells Yueh-Hsiang Yu and Kuo-I Lin 3. Deep Profiling Human T Cell Heterogeneity by Mass Cytometry Yang Cheng and Evan W. Newell 4. Germinal Center B-cell-associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell Maturation Nobuo Sakaguchi and Kazuhiko Maeda 5. Advances in PET Detection of the Anti-Tumor T Cell Response Melissa N. McCracken, Richard Tavare, Owen N. Witte and Anna Wu

Volume: v. 129 ISBN 9780128047996

Description

Table of Contents

1. Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: a New Hypothesis for Autoimmune Diseases Hisashi Arase 2. Mechanism of Diapedesis: Importance of the Transcellular Route Marie-Dominique Filippi 3. Evolution of the Humoral Response during HCV Infection: Theories of the Origin of Broadly Neutralizing Antibodies and Implications on Vaccine Design Armstrong Murira and Alain Lamarre 4. Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control Ellen V. Rothenberg, Jonas Ungerback and Ameya Champhekar 5. Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroidits, and Hematopoietic Stem Cell Translantation Takehiko Sasazuki, Hidetoshi Inoko, Satoko Morishima and Yasuo Morishima 6. The Pathogenesis and Immunobiology of Mousepox Luis J. Sigal 7. MAP4K Family Kinases in Immunity and Inflammation Huai-Chia Chuang, Xiaohong Wang and Tse-Hua Tan

Volume: v. 135 ISBN 9780128124055

Description

Advances in Immunology, Volume 135, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this latest update including chapters on GPCR Biology, the Role of Caveolin-1 in BCR and TCR Receptors, New Developments in the Chemokine Field, and The Complement System in Developmental Neurobiology and Neurodegeneration. Readers will find comprehensive information on molecular and cellular activation mechanisms, phylogeny and molecular evolution and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Table of Contents

1. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases Sudipta Das, Marina Miller and David H. Broide 2. Complement System in Neural Synapse Elimination in Development and Disease Jessy Presumey, Allison R. Bialas and Michael C. Carroll 3. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection Xing Liu and Judy Lieberman 4. Chemokine-Driven CD4+ T Cell Homing: New Concepts and Recent Advances Carly E. Gregor, Jade Foeng, Iain Comerford and Shaun R. McColl

Volume: v. 134 ISBN 9780128124079

Description

Advances in Immunology, Volume 134, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Topics covered in this new volume include ?d T Cells and B Cells, A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes. Tissue Specific Regulation of Dendritic Cell Development and Function, and the Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFss). Articles in this long running series address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Table of Contents

1. ?d T Cells and B Cells W.K. Born, Y. Huang, R.L Reinhardt, H. Huang, D. Sun and R.L. O'Brien 2. A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes V.Y. Lim, S. Zehentmeier, C. Fistonich and J.P. Pereira 3. Tissue Specific Regulation of Dendritic Cell Development and Function D. Pakalniskyte and B.U. Schraml 4. Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFss) A. Kelly, S.A. Houston, E. Sherwood, J. Casulli and M.A. Travis 5. Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem L. Verkoczy

Volume: v. 133 ISBN 9780128124093

Description

Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Table of Contents

1. Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity 2. Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination 3. Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5 4. Nucleic Acid Immunity 5. About Training and Memory: NK-Cell Adaptation to Viral Infections

Volume: v. 140 ISBN 9780128151860

Description

Advances in Immunology, Volume 140, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology.

Table of Contents

1. Regulatory T cells Harvey Cantor 2. The immunological synapse and T cell signaling Michael Loran Dustin 3. Drosophila immunity and homeostasis during viral infection Jonathan Kagan

Volume: v. 139 ISBN 9780128151877

Description

Advances in Immunology, Volume 139, the latest issue of a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Alzheimer's and its innate receptors, the field of immune orchestration by small molecules, like chemokines and lipids, the role of AID in the first checkpoint, and the design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies.

Table of Contents

1. The Microglial Response to Neurodegenerative Disease Wilbur M. Song and Marco Colonna 2. The First Tolerance Checkpoint in Mice and Humans: Control by AID Masayuki Kuraoka, Eric Meffre and Garnett Kelsoe 3. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes Sherry Lin, Zhaoqing Ba, Frederick W. Alt and Yu Zhang

Volume: v. 138 ISBN 9780128151884

Description

Advances in Immunology, Volume 138, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Eosinophil Development, Disease Involvement, and Therapeutic Suppression, Immunoglobulin A responses to the microbiota, Unexpected roles for intracellular complement in the regulation of TH1 responses, Magnesium in T cell signaling, and immunological synapse and T cell signaling.

Table of Contents

1. Eosinophil Development, Disease Involvement, and Therapeutic Suppression Marc E. Rothenberg 2. Immunoglobulin A responses to the microbiota Oliver Pabst 3. Unexpected roles for intracellular complement in the regulation of TH1 responses Olivia Kemper 4. Magnesium in T cell signaling Michael Lenardo 5. The immunological synapse and T cell signaling Michael Loran Dustin

Volume: v. 137 ISBN 9780128151891

Description

Advances in Immunology, Volume 137, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including sections on Notch and T-Cell signaling/T-Cell memory, Single Cell Analysis of CD8+ and CD4+ T Cell Differentiation, New Developments in the Chemokine Field, the Role of Caveolin-1 in BCR and TCR Receptors, The Unusual Biochemistry of Bovine Immunoglobulins, and the Molecular Aspects of Allergens and Allergy.

Table of Contents

1. Single-Cell Resolution of T Cell Immune Responses Veit R. Buchholz and Michael Flossdorf 2. The Fate Choice Between Effector and Memory T Cell Lineages: Asymmetry, Signal Integration, and Feedback to Create Bistability Ronald A. Backer, Pleun Hombrink, Christina Helbig and Derk Amsen 3. Caveolin-1: The Unnoticed Player in TCR and BCR Signaling Gina J. Fiala and Susana Minguet 4. The Unusual Genetics and Biochemistry of Bovine Immunoglobulins Robyn L. Stanfield, Jeremy Haakenson, Thaddeus C. Deiss, Michael F. Criscitiello, Ian A. Wilson and Vaughn V. Smider

Volume: v. 141 ISBN 9780128177020

Description

Advances in Immunology, Volume 141, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this volume focusing on recent advances in the cysteinyl leukotriene pathway and chromosome biology and immunology.

Table of Contents

1. Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics Waradon Sungnak, Chao Wang and Vijay K. Kuchroo 2. Transcription factories in Ig? allelic choice and diversity Sophiya Karki, Shiladitya Banerjee, Kaitlin Mclean, Aaron Dinner and Marcus R. Clark 3. Cis- and trans-factors affecting AID targeting and mutagenic outcomes in antibody diversification Leng-Siew Yeap and Fei-Long Meng 4. Signaling control of antibody isotype switching Zhangguo Chen and Jing H. Wang

Volume: v. 142 ISBN 9780128177044

Description

Advances in Immunology, Volume 142, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies.

Table of Contents

1. The airway epithelium in asthma Luke R. Bonser and David J. Erle 2. Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond Sophie Laffont and Jean-Charles Guery 3. Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions Yoshihide Kanaoka and K. Frank Austen 4. Airway mycosis in allergic airway disease Evan Li, J. Morgan Knight, Yifan Wu, Amber Luong, Antony Rodriguez, Farrah Kheradmand and David B. Corry

Volume: v. 143 ISBN 9780128177068

Description

Advances in Immunology, Volume 143, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on the design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies, gender bias, fungi, fibrinolysis and allergic airway inflammation, updating and interpreting airway epithelial cell reprogramming in bronchial asthma, the link(s) of sensing to the immune response, and the regulatory role of the autonomic system.

Table of Contents

1. Neuronal regulation of group 2 innate lymphoid cells and type 2 inflammation Saya Moriyama and David Artis 2. Antibody responses to the HIV-1 envelope high mannose patch Christine Daniels and Kevin O. Saunders 3. Origin and function of synovial macrophage subsets during inflammatory joint disease Stephan Culemann, Anika Gruneboom and Gerhard Kroenke 4. Models of dendritic cell development correlate ontogeny with function David A. Anderson III and Kenneth M. Murphy

Volume: v. 146 ISBN 9780128207390

Description

Advances in Immunology, Volume 146, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on The design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies, T cells in latent viral infections, Preserving Immune Homeostasis with A20, Transcriptional control in the context of innate and adaptive lymphoid development, RAG and AID structural biology and the important insights it has generated for the V(D)J recombination and CSR/SHM fields, and more.

Table of Contents

1. The design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies Joseph Jardine 2. T cells in latent viral infections Dietmar Zehn 3. Preserving Immune Homeostasis with A20 Averil Ma 4. Transcriptional control in the context of innate and adaptive lymphoid development Barbara Kee 5. RAG and AID structural biology and the important insights it has generated for the V(D)J recombination and CSR/SHM fields Heng Ru 6. The advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies Mattia Bonsignori 7. Normal Microbiota inducing disease Martin Kriegel 8. Plasma Cell Sub-populations Wolfgang Schuh

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