Brain tumors : principles of biology, diagnosis and therapy
著者
書誌事項
Brain tumors : principles of biology, diagnosis and therapy
（Handbook of clinical neurology, v. 67 = rev. ser. 23 . Neuro-oncology ; pt. 1）
Elsevier, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Neuro-Oncology is a three-part coverage of that subject over three volumes, with a comprehensive and multidisciplinary approach. This first section deals with fundamental aspects including ontogeny, classification and genetic defects of brain tumors. Correct diagnosis is crucial and ample attention is devoted to the clinical setting defined by the boundaries of epidemiological data, neurological signs and symptoms, indicating either focal or diffuse involvement of the nervous system. Consistently thorough, the volume explains how there can be more symptoms than caused by the tumor itself. Advances in neuropathology, including histochemical techniques, are enabling us to get a better grip on the nature and degree of malignancy in tumors. The final word on the efficacy of any treatment depends on the results of clinical trials for which the proper methodology, including design and statistic requirements, is discussed. Neurotoxicity is another aspect of major concern and interest adequately handled in this work. Neuro-Oncology Part I therefore concludes with a discussion on the neurotoxic effects of brain-targeted therapy.
目次
In Memoriam Dr Macdonald Critchley - G.W. Bruyn.
Foreword. List of contributors.
I. Biology Of Brain Tumors.
1. Ontogeny and classification of brain tumors (M.B.S. Lopes, B.W. Scheithauer, S.R. VandenBerg). 2. Regulatory pathways in normal and tumor cells (E.C. Zwarthoff). 3. Molecular genetics of hereditary and non-hereditary central nervous system tumors (E.J. Dropcho). 4. Brain tumor edema and the role of the blood-brain barrier (A.F. Samdani, R.J. Tamargo, D.M. Long). 5. Pseudotumor cerebri (benign intracranial hypertension): mechanisms, causes and therapy (S.M. Al Deeb, B.A. Yaqub, G.W. Bruyn).
II. General Aspects Of Diagnosis And Therapy Of Brain Tumors.
6. Epidemiology of brain tumors (N.I. Bohnen, L.T. Kurland). 7. Signs of focal lesions and of increased intracranial pressure in brain tumors (K.A. Jaeckle). 8. Brain tumor imaging (R.A. Zimmerman). 9. Neuro-imaging of spinal tumors (G. Krol). 10. Laboratory diagnosis of brain tumors (J.M. Kros). 11. Principles and new techniques in neurosurgery (T.C. Chen, M.L.J. Apuzzo). 12. Principles and new techniques in radiotherapy (M. Brada, G. Ross). 13. Principles and application of chemotherapy in brain tumors (P.L. Kornblith, W.C. Welch). 14. Immunotherapy and gene therapy (P.A.E. Sillevis Smitt, G.T. Manley). 15. Methodology of clinical trials in brain tumors (J. Hildebrand, T. Sahmoud).
III. Neurotoxicity and Quality of Life.
16. Radiation damage to the brain (K. Peterson, D.A. Rottenberg). 17. Combined radiation and chemotherapy-induced disorders of the brain and spinal cord (M.C. Vigliani, R. Yaya-Tur, J.-Y. Delattre). 18. Radiation-induced cognitive dysfunction in adults (M.C. Vigliani, C. Duyckaerts, J.-Y. Delattre). 19. Issues of quality of life in neuro-oncology (C.A. Meyers).
Index.
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